An evening peel-effect serum that fades stubborn dark spots
Isispharma Neotone Serum is an intensive night serum for dark spots and uneven skin tone on the face, décolleté and hands, whether they come from the sun, age or hormonal changes. It combines glycolic and salicylic acids, which give a gentle surface peel and speed up cell renewal, with Isispharma's DEPI-ACT complex (diacetyl boldine and trimethoxybenzyl acetylsinapate), niacinamide and licorice root extract, which target the look of pigmentation and brighten the complexion. In a clinical study with Neotone Radiance SPF50+ used by day, the intensity of dark spots was reduced by 43%.
The texture
A light, fluid serum that spreads easily over spots or the whole face and absorbs quickly, with a smooth, slightly silky finish from the silicones. It can tingle a little on application, which is normal with acids.
Who it suits
- Sun spots, age spots and melasma-prone skin
- Dark marks left by old blemishes
- Dull, uneven complexion
- Anyone ready to commit to daily SPF during treatment
Worth knowing before you buy: it contains glycolic and salicylic acids, alcohol and fragrance, so it can sting sensitive or freshly shaved skin. Skin is more sun-sensitive while you use it: a high SPF every morning is essential, or spots will come back.
How long one tube lasts
Applied every evening to the face, the 30ml tube lasts about two months, longer if you only treat individual spots.
Complete the routine

Neotone Radiance SPF50+
The daytime partner used in the clinical study.
Shop →
Neotone Body
The same approach for dark spots on the body.
Shop →Characteristics
- Texture: fluid serum
- Skin type: all skin types
- Skin concerns: dark spots, hyperpigmentation, uneven tone
- When to apply: in the evening
- Main benefits: reduces dark spots, evens and brightens skin tone, gentle peel effect, stimulates cell renewal
How to use
Apply every evening to clean, dry skin on the face, décolleté or hands, on the spots or over the whole area, avoiding the eye contour. During the day, protect treated areas with a high SPF such as Neotone Radiance SPF50+ or an Uveblock sunscreen. Avoid contact with the eyes.
Active ingredients
- Glycolic acid and salicylic acid: gentle peel effect that renews the skin surface
- DEPI-ACT complex (diacetyl boldine, trimethoxybenzyl acetylsinapate): targets the look of dark spots
- Niacinamide: evens tone and brightens
- Licorice root extract: helps brighten and soothe
Ingredients
AQUA (WATER) · DIMETHICONE · GLYCOLIC ACID · CAPRYLIC/CAPRIC TRIGLYCERIDE · ALCOHOL DENAT. · GLYCERIN · ISOPENTYLDIOL · NIACINAMIDE · SODIUM HYDROXIDE · POLYACRYLATE CROSSPOLYMER-6 · 1,2-HEXANEDIOL · BENTONITE · HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER · HYDROXYETHYLCELLULOSE · SALICYLIC ACID · DIMETHICONE/VINYL DIMETHICONE CROSSPOLYMER · PARFUM (FRAGRANCE) · CHLORPHENESIN · BETA-GLUCAN · ALGIN · CITRIC ACID · XANTHAN GUM · BENZOIC ACID · POLYSORBATE 60 · SORBIC ACID · SORBITAN ISOSTEARATE · T-BUTYL ALCOHOL · DISODIUM PHOSPHATE · HYDRATED SILICA · SODIUM PHOSPHATE · GLYCYRRHIZA GLABRA (LICORICE) ROOT EXTRACT · TRIMETHOXYBENZYL ACETYLSINAPATE · DIACETYL BOLDINE
Formulations are updated by the manufacturer from time to time. Always check the packaging you receive.
Manufacturer information
Brand: Isispharma France
Address: 29 avenue de la Marne, Parc des 3 Chênes, 59290 Wasquehal, France
EAN: 3760269770362