A daily blemish treatment that works on spots, blackheads and marks
Avène Cleanance Comedomed+ Intensive Anti-Blemish Care is a daily treatment for oily, acne-prone skin that targets pimples, blackheads and post-acne marks at their root, and helps prevent new ones from forming, with the brand citing up to one year of prevention. Its key active is Comedoclastin, a plant-based ingredient from milk thistle, used here at 25%, which acts on both micro-comedones and micro-inflammation, two of the main triggers of breakouts. It is paired with 4% niacinamide, which helps fade marks and refine the look of pores, and Avène Thermal Spring Water, which soothes. The brand reports that imperfections start to look reduced within five hours, with blackheads, spots and marks clearly diminished over the following weeks, and its efficacy has been studied on more than 4,600 people. It provides 24-hour hydration, is suitable from age 9 and can be used alongside acne medications. The formula is fragrance-free, oil-free, silicone-free and non-comedogenic.
The texture
A light gel-cream that absorbs quickly without a greasy or sticky finish. It sits comfortably under sunscreen or makeup and leaves the skin fresh rather than shiny, which suits oily and combination skin. Only a small amount is needed to cover the whole face.
Who it suits
- Oily, acne-prone skin with regular breakouts
- Blackheads and whiteheads on the nose, chin and forehead
- Red or brown marks left after spots
- Teenagers from age 9 and adults with adult acne
- Anyone who wants one treatment instead of several spot products
- Skin already using acne treatments that needs a gentle, compatible partner
Worth knowing before you buy: the formula contains isopropyl alcohol, which gives the fresh finish but can feel drying on very sensitive or dry skin. Blemish treatments can make skin more reactive, so wear a daily sunscreen, such as the Cleanance SPF50+ below. Results build over time, so give it at least four weeks of twice-daily use before judging.
How long one bottle lasts
Used morning and evening on the whole face, the 30ml bottle lasts around five to six weeks, longer if you only apply it to breakout-prone areas.
Complete the routine

Cleanance Cleansing Gel
A soap-free wash for oily, blemish-prone skin.
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Cleanance SPF50+
A matte daily sunscreen for acne-prone skin.
Shop →Characteristics
- Texture: light gel-cream
- Skin type: oily, acne-prone skin
- Skin concerns: blackheads, whiteheads, pimples, post-acne marks
- When to apply: morning and/or evening
- Age: 9+
- Main benefits: targets pimples, blackheads and post-acne marks, helps prevent new breakouts, refines pores, 24-hour hydration, non-comedogenic, soothing, compatible with acne treatments
- Formulated without: fragrance, oil, parabens, silicones
How to use
Apply to clean, dry skin morning and evening, over the whole face or on breakout-prone areas. Follow with a sunscreen in the morning.
Active ingredients
- Comedoclastin (25%, milk thistle fruit extract): acts on micro-comedones and micro-inflammation at the root of blemishes
- Niacinamide (4%): helps fade post-acne marks and refine pores
- Avène Thermal Spring Water: soothes and calms
Ingredients
AVENE THERMAL SPRING WATER (AVENE AQUA) · ISOPROPYL ALCOHOL · PEG-6 · GLYCERIN · NIACINAMIDE · SILYBUM MARIANUM FRUIT EXTRACT · SILICA · POLYACRYLATE-13 · POLYISOBUTENE · POLYSORBATE 20 · SORBITAN ISOSTEARATE · WATER (AQUA)
Formulations are updated by the manufacturer from time to time. Always check the packaging you receive.
Manufacturer information
Brand: Laboratoires Dermatologiques Avène
Address: Les Cauquillous, 81506 Lavaur Cedex, France
EAN: 3282770399226
