An overnight comfort cream for skin that reacts to almost everything
La Roche-Posay Toleriane Dermallergo Night Cream is a soothing night moisturizer for sensitive, very reactive skin, built on a minimal, fragrance-free formula. It contains Sphingobioma, a probiotic-derived ingredient that helps support the skin surface and the skin barrier, together with Neurosensine and 2% niacinamide to calm discomfort. Tightness, redness and dryness are soothed straight away, and the skin is comforted overnight, with hydration for up to 48 hours.
The texture
A soft gel-cream that melts in quickly and leaves no greasy film on the pillow. It is completely fragrance-free.
Who it suits
- Sensitive or very reactive skin that reacts to many products
- Skin that feels tight, uncomfortable or red by the end of the day
- Anyone simplifying a routine after a reaction
- Teens and adults, from 10 years old
Worth knowing before you buy: It is a comforting moisturizer, not an anti-ageing cream, so it has no retinol or exfoliating acids. Pair it with the Dermallergo day cream in the morning for round-the-clock soothing.
How long one tube lasts
Used every evening on face and neck, the 40ml tube lasts around two months.
Complete the routine

Dermallergo Day Cream
The daytime partner for reactive skin.
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Dermallergo Eye Cream
Soothing care for sensitive eye contours.
Shop →Characteristics
- Texture: gel-cream
- Skin type: all skin types, including sensitive and very reactive
- Skin concerns: sensitivity, redness, tightness, dryness
- When to apply: evening
- Age: 10+
- Main benefits: soothes instantly, supports the skin barrier overnight, helps keep the skin surface balanced, 48-hour hydration
- Formulated without: fragrance, alcohol
How to use
Apply in the evening to clean, dry face and neck.
Active ingredients
- Sphingobioma: probiotic-derived ingredient that helps support the skin surface and the skin barrier
- Neurosensine: reduces feelings of discomfort and skin reactivity
- Niacinamide (2%): calms the skin and helps reinforce the skin barrier
- Vitamin B6: soothes and helps minimise redness
Ingredients
AQUA / WATER / EAU · GLYCERIN · BUTYLENE GLYCOL · PROPANEDIOL · BUTYROSPERMUM PARKII BUTTER / SHEA BUTTER · PENTYLENE GLYCOL · SQUALANE · NIACINAMIDE · AMMONIUM POLYACRYLOYLDIMETHYL TAURATE · PYRIDOXINE HCl · POLYSORBATE 20 · ZEA MAYS STARCH / CORN STARCH · SALVIA MILTIORRHIZA ROOT EXTRACT · ALLANTOIN · GLYCERYL ACRYLATE/ACRYLIC ACID COPOLYMER · SODIUM HYDROXIDE · SPHINGOMONAS FERMENT EXTRACT · HYDROXYACETOPHENONE · CAPRYLYL GLYCOL · CITRIC ACID · TRISODIUM ETHYLENEDIAMINE DISUCCINATE · ACETYL DIPEPTIDE-1 CETYL ESTER · XANTHAN GUM · TOCOPHEROL
Formulations are updated by the manufacturer from time to time. Always check the packaging you receive.
Manufacturer information
Brand: La Roche-Posay Laboratoire Dermatologique
Address: 86270 La Roche-Posay, France
EAN: 3337875800853
