The strongest Glyco-A night peel for smoother, more even skin
Isispharma Glyco-A Intense Peeling Night Cream 25% is a leave-on night peel for mature skin with wrinkles, dark spots and a dull, uneven tone. It contains 25% glycolic acid, the most concentrated cream in the Glyco-A range, together with mandelic acid and gluconolactone. These acids loosen dead cells to boost cell renewal, so the skin looks smoother, firmer and more even. In a brand study on 21 volunteers over 28 days, all reported a more even complexion.
The texture
A light, smooth cream that spreads in a thin layer and is left on overnight, with no rinsing. A slight tingling is common on the first nights while the skin gets used to the acids.
Who it suits
- Mature skin with fine lines and wrinkles
- Dark spots and uneven, dull skin tone
- Skin already used to glycolic acid at lower strengths
- Anyone wanting a peel-type result at home
Worth knowing before you buy: At 25% this is a strong acid. If you are new to glycolic acid, start with the Glyco-A Medium 12% cream first. Daily sunscreen is essential while using it, and the brand does not recommend it during pregnancy or breastfeeding.
How long one tube lasts
Used as directed, two to three evenings a week in a thin layer, the 30ml tube usually lasts three to four months.
Complete the routine

Glyco-A Post Peeling
The soothing cream to use the morning after.
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Neotone Radiance SPF50+
Daily high protection for skin prone to dark spots.
Shop →Characteristics
- Texture: light cream
- Skin type: mature skin, skin used to acids
- Skin concerns: wrinkles, dark spots, dull and uneven tone, loss of firmness
- When to apply: in the evening, 2 to 3 times a week
- Main benefits: exfoliates, boosts cell renewal, evens the complexion, smooths
- Formulated without: fragrance, parabens
How to use
Two to three evenings a week, massage a thin layer onto clean, dry skin, avoiding the eye contour and lips. Leave on overnight. The next morning, apply Glyco-A Post Peeling and a high-SPF sunscreen. Do not use on irritated or broken skin.
Active ingredients
- Glycolic acid (25%): exfoliates and boosts cell renewal for smoother, more even skin
- Mandelic acid: a gentler AHA that helps even out skin tone
- Gluconolactone: a mild PHA that adds exfoliation with extra comfort
- Jojoba esters and sunflower seed wax: help keep the skin comfortable
Ingredients
Aqua (Water) · Glycolic Acid · Glyceryl Stearate · Isodecyl Neopentanoate · Dimethicone · Mandelic Acid · PEG-100 Stearate · Magnesium Aluminum Silicate · Ceteareth-20 · Gluconolactone · Ammonia · Glycerin · Sorbitan Stearate · Sodium Hydroxide · Jojoba Esters · Helianthus Annuus (Sunflower) Seed Wax · Sclerotium Gum · Xanthan Gum · Acacia Decurrens Flower Wax · Polyglycerin-3
Formulations are updated by the manufacturer from time to time. Always check the packaging you receive.
Manufacturer information
Brand: Isispharma France
Address: 29 avenue de la Marne, Parc des 3 Chênes, 59290 Wasquehal, France
EAN: 3760269771611
