A 40% urea treatment for thick, rough and hardened skin
ISDIN Ureadin Ultra 40 is a highly concentrated exfoliating oil-gel for localized areas of thickened, hardened skin. With 40% urea, it is one of the strongest urea treatments in the ISDIN Ureadin range. At this level, urea works as a keratolytic: it softens and loosens the hard, built-up layers of skin on calluses, cracked heels, elbows and knees, and on thickened nails, so they can be gradually smoothed away. Glycerin and allantoin help keep the treated areas hydrated and comfortable.
The texture
An oil-gel that is richer than a gel but less heavy than a balm. It is applied in a thin layer only on the hardened areas and absorbs in a few minutes. It has a light fragrance.
Who it suits
- Rough, cracked heels and calluses on the feet
- Thickened skin on elbows and knees
- Thick, hardened nails that need softening
- Anyone who finds classic foot creams too weak
Worth knowing before you buy: At 40% urea, this is a strong keratolytic. Apply it only to thickened areas, not to the face, mucous membranes or broken skin, and wash your hands after use. The formula contains fragrance. For everyday dry skin on the body, the milder Ureadin Ultra 10 lotion is a better fit.
How long one tube lasts
Used once or twice a day on heels or a few small areas, the 30ml tube usually lasts three to four weeks.
Complete the routine

Ureadin Ultra 10 Plus
Repairing lotion for dry skin all over.
Shop →
Ureadin Hydrating Cream
Daily moisture for dry skin.
Shop →Characteristics
- Texture: oil-gel
- Skin type: thickened, hardened, very rough skin
- Skin concerns: calluses, cracked heels, rough elbows and knees, thickened nails
- When to apply: once or twice a day, on the affected areas only
- Main benefits: softens and exfoliates hardened skin, smooths rough areas, hydrates
How to use
Apply a thin layer to the thickened areas once or twice a day and massage gently until absorbed. For nails, apply to the nail surface. Avoid contact with eyes, mucous membranes and healthy surrounding skin, and wash your hands after each use. Once the skin is smoother, space out applications.
Active ingredients
- Urea (40%): a high concentration that softens and loosens hardened, thickened skin and nails
- Glycerin: a humectant that keeps the treated skin hydrated
- Allantoin: helps keep the skin comfortable
- Lactic acid: supports gentle exfoliation
Ingredients
Urea · Aqua (Water) · Glycerin · Isononyl Isononanoate · Octyldodecanol · Carbomer · Arginine · Dimethicone · Cyclopentasiloxane · Phenoxyethanol · Octyldodecyl Xyloside · PEG-30 Dipolyhydroxystearate · Cyclohexasiloxane · Laureth-9 · Lactic Acid · Parfum (Fragrance) · Allantoin · Disodium EDTA · Ethylhexylglycerin · Limonene · Hexyl Cinnamal · Alpha-Isomethyl Ionone · Linalool · Benzyl Salicylate · Eugenol · Citral · Hydroxycitronellal · Coumarin · Geraniol · Citronellol · Cinnamyl Alcohol · Isoeugenol
Formulations are updated by the manufacturer from time to time. Always check the packaging you receive.
Manufacturer information
Brand: ISDIN S.A.
Address: Provençals 33, 08019 Barcelona, Spain
EAN: 8429420104679
